Shaw Cross Sharks and Thornhill Trojans will be aiming to overcome tough initial hurdles, following the draw for the first round of the Ladbrokes Challenge Cup.
Shaw Cross have been drawn at home to Beverley, while Thornhill will make the short trip to face East Leeds.
In a first for the Challenge Cup, London Chargers were drawn at home against Hammersmith Hills Hoists in an all-London fixture.
Scottish Champions Strathmore Silverbacks will travel to Cumbria to face Millom in the first round.
West Hull will welcome the first Irish side to enter the Cup since 1998, Longhorns.
All first-round ties will be played over the weekend of January 27-28.